Pyinstaller on Windows Prerequisites 64-bit Windows 2008/7 Python 2.7.10 x86 1 pip virtualenv Microsoft Visual C++ 2008 Redistributable Package (x86) or MSVC Compiler for Pyhton 2.7 2 Create and activate virtualenv virtualenv c:\venv\pyapp cd c:\venv\pyapp\Scripts activate From now on, we’ll be working within a virtualenv environment. PowerShell If you would like to give PowerShell a try like me. Before activate your virtualenv , you need to change your script execution policy via Set-ExecutionPolicy RemoteSigned in a privileged PowerShell terminal. Install pywin32 and pyinstaller easy_install http://sourceforge.net/projects/pywin32/files/pywin32/Build %20219 /pywin32 -219 .win32-py2. 7 .exe /download pip install pyinstaller The msvcr90.dll Problem There is a known issue was discussed on StackOverflow . Quick solution is to install the specific Microsoft Visual C++ 2008 Redistributable Package (x86) which can be downloaded here . If...